| CD22 molecule | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CD22; FLJ22814; MGC130020; SIGLEC-2; SIGLEC2 | ||||||||||||
| External IDs | OMIM: 107266 MGI: 88322 HomoloGene: 31052 GeneCards: CD22 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 933 | 12483 | |||||||||||
| Ensembl | ENSG00000012124 | ENSMUSG00000030577 | |||||||||||
| UniProt | P20273 | Q3T9T5 | |||||||||||
| RefSeq (mRNA) | NM_001185099.1 | NM_001043317 | |||||||||||
| RefSeq (protein) | NP_001172028.1 | NP_001036782 | |||||||||||
| Location (UCSC) | Chr 19: 35.82 – 35.84 Mb |
Chr 7: 31.65 – 31.67 Mb |
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| PubMed search | [1] | [2] | |||||||||||
CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.[1] It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.[2]
CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling.
An immunotoxin, BL22, that targets this receptor is being tested at the NIH.[3]
CD22 has been shown to interact with Grb2,[4][5] PTPN6,[6][5][7][8][9] LYN,[4][7] SHC1[4] and INPP5D.[4]
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